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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
STK11
All Species:
25.15
Human Site:
S422
Identified Species:
39.52
UniProt:
Q15831
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15831
NP_000446.1
433
48636
S422
R
K
A
C
S
A
S
S
K
I
R
R
L
S
A
Chimpanzee
Pan troglodytes
XP_524028
433
48572
S422
R
K
A
C
S
A
S
S
K
I
R
R
L
S
A
Rhesus Macaque
Macaca mulatta
XP_001093806
433
48511
S422
R
K
A
C
S
A
S
S
K
I
R
R
L
S
A
Dog
Lupus familis
XP_542206
439
49298
S428
R
K
A
C
S
A
S
S
K
I
R
R
L
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9WTK7
436
49248
N425
A
R
K
V
C
S
S
N
K
I
R
R
L
S
A
Rat
Rattus norvegicus
NP_001101539
436
49227
N425
A
R
K
V
C
S
S
N
K
I
R
R
L
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519859
324
36639
H314
V
P
Y
L
E
D
L
H
G
Y
N
V
T
R
I
Chicken
Gallus gallus
Q0GGW5
440
49774
S426
N
P
S
R
K
A
C
S
A
S
S
K
I
R
K
Frog
Xenopus laevis
Q91604
432
49054
S421
R
K
A
S
T
T
G
S
K
V
R
K
L
S
A
Zebra Danio
Brachydanio rerio
NP_001017839
440
49807
S429
R
K
G
L
S
A
A
S
K
I
R
K
L
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650302
567
62874
I556
A
K
K
L
T
S
C
I
S
V
R
K
L
S
H
Honey Bee
Apis mellifera
XP_623596
434
50409
R418
Q
N
S
H
Q
S
K
R
R
W
R
K
P
I
S
Nematode Worm
Caenorhab. elegans
Q9GN62
617
69630
G566
A
P
P
G
P
A
A
G
N
A
Q
N
S
T
A
Sea Urchin
Strong. purpuratus
XP_780778
429
48923
S417
P
Q
K
E
K
K
I
S
R
V
R
K
L
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q38997
535
61163
A485
S
S
I
I
E
N
E
A
A
V
K
S
P
N
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
99.3
92.4
N.A.
90.1
90.5
N.A.
57.7
89.3
81.2
82.2
N.A.
41.4
54.6
29.8
57.7
Protein Similarity:
100
99.3
99.5
94.5
N.A.
93.3
93.1
N.A.
63.2
93.1
87.5
87.2
N.A.
54.8
71.8
43.7
72.2
P-Site Identity:
100
100
100
100
N.A.
53.3
53.3
N.A.
0
13.3
60
66.6
N.A.
26.6
6.6
13.3
26.6
P-Site Similarity:
100
100
100
100
N.A.
73.3
73.3
N.A.
0
33.3
80
80
N.A.
53.3
46.6
33.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
43.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
27
0
34
0
0
47
14
7
14
7
0
0
0
0
54
% A
% Cys:
0
0
0
27
14
0
14
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
7
14
0
7
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
7
7
0
0
7
7
7
0
0
0
0
0
0
% G
% His:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
7
% H
% Ile:
0
0
7
7
0
0
7
7
0
47
0
0
7
7
7
% I
% Lys:
0
47
27
0
14
7
7
0
54
0
7
40
0
0
7
% K
% Leu:
0
0
0
20
0
0
7
0
0
0
0
0
67
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
7
0
0
0
7
0
14
7
0
7
7
0
7
0
% N
% Pro:
7
20
7
0
7
0
0
0
0
0
0
0
14
0
0
% P
% Gln:
7
7
0
0
7
0
0
0
0
0
7
0
0
0
0
% Q
% Arg:
40
14
0
7
0
0
0
7
14
0
74
40
0
14
0
% R
% Ser:
7
7
14
7
34
27
40
54
7
7
7
7
7
67
14
% S
% Thr:
0
0
0
0
14
7
0
0
0
0
0
0
7
7
7
% T
% Val:
7
0
0
14
0
0
0
0
0
27
0
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _